Key Research Articles
- Structure based discovery of opioid analgesics with reduced side effects. Nature. (2016) doi:10.1038/nature19112.
Manglik A*, Lin H*, Aryal D*, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hubner H, Huang XP, Sassano MF, Giguere P, Lober S, Duan D, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. - Allosteric nanobodies reveal the dynamic range and diverse mechanisms of GPCR activation. Nature. (2016) 535(7612):448-52.
Staus DP*, Strachan RT*, Manglik A*, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. - Structural insights into μ-opioid receptor activation. Nature. (2015) 524(7565):315-21.
Huang W*, Manglik A*#, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling R, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK#. (# Corresponding Author) - Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. (2015) 161(5):1101-11.
Manglik A*, Kim TH*, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. - Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. (2013) 502(7472):575-9.
Ring AM*, Manglik A*, Kruse AC*, Enos MD, Weis WI, Garcia KC, Kobilka BK. - Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. (2013) 497(7447):137-41.
Shukla AK*, Manglik A*, Kruse AC*, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. - Structure of the δ-opioid receptor bound to naltrindole. Nature. (2012) 485(7398):400-4.
Granier S, Manglik A*, Kruse AC*, Kobilka TS, Thian FS, Weis WI, Kobilka BK. - Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. (2012) 485(7398):321-6.
Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.
